THE SECRET IS IN THE SCIENCE
WHAT IS HIMMENSE SHIFT?

It’s a daily hydrolysed Marine Collagen supplement infused with Vitamins C, D, B12, B6, B5 (Pantothenic Acid), Selenium and Ashwagandha that supports physical and mental wellbeing. Benefits associated with the nutrients in HIMMENSE SHIFT range from skin, heart, joint, gut, and sexual health to improved muscle mass and strength.

WHAT DO THE STUDIES SHOW?

Expand on the headers below to check out the multiple benefits and the links to clinical studies behind the key nutrients in HIMMENSE SHIFT.

COLLAGEN

WHAT IS COLLAGEN?

The star ingredient in HIMMENSE SHIFT is hydrolysed marine collagen. Marine collagen is classified as a type I collagen, which is the most abundant type of collagen found in the body. Clinical studies show that there are several benefits associated with taking marine collagen supplements. But first, let’s start with the basics. What is collagen?

Collagen is the second most abundant substance in our body, after water. It’s the most abundant structural protein in the human body. Collagen is often called the body’s scaffolding. It’s the glue that holds the body together and is found in skin, muscles, tendons, ligaments, bones and all our connective tissues, with its purpose being to provide these body parts with their strength, structure, and elasticity.

As we get older, our bodies become less efficient at naturally producing collagen which is why so many people supplement their diet with collagen to keep their bodies in optimal working condition.

WHAT DOES COLLAGEN DO?

Collagen has many important functions and is a major structural protein found in our bodies, both internally and externally. It’s the primary building block, composed of amino acids, that provide our skin, hair, nails, organs, bones, tendons, ligaments and blood vessels with structural support and strength. This naturally occurring protein is found in our body in large amounts and helps to keep us strong and fit.

Collagen makes up about a third of all the protein in the human body, more than any other type of protein in the body by mass. Collagen - which is rich in amino acids, including proline, glycine and hydroxyproline – plays such an important role in the body that it specifically makes up about 70-75% of our dry-mass skin content, providing volume that keeps skin looking plump and keeps lines at bay.

Our bodies make collagen, in a process known as collagen synthesis, by combining different amino acids extracted from our diet.

Scientists have identified twenty-eight different types of collagen (each ‘type’ is a different combination of amino acids). But in humans, the vast majority is type I, II, or III.

  • type I is the most common type of collagen – found in skin, hair, nails, bone, teeth, tendons, ligaments, blood vessels, and organs such as the heart, lungs, and others.
  • type II collagen is mainly found in cartilage.
  • type III collagen is present in the skin, muscle, and blood vessels.

The majority, as much as 90%, of the body’s collagen is type I.

WHAT HAPPENS TO COLLAGEN AS WE AGE?

Our body’s ability to synthesise collagen declines gradually as we get older. As we age, we break down collagen faster than we can replace it, and our natural collagen production begins to slow down, which can result in sagging skin, the appearance of fine lines, thinning hair, and joint stiffness for example. As we age, our bodies also make lower quality collagen too.

We begin to lose about 1% of our collagen per year in our mid-20s. By the time we get to 40, we will have lost around a third of our natural collagen, and the visible signs of ageing become more prominent. Excess sun UV exposure, smoking and poor diet can also inhibit our natural collagen production and speed up the rate at which our collagen levels deplete.

There have been some impressive clinical studies (which we highlight below) that show that supplementing our diet with ingestible collagen may stimulate the body into producing collagen on its own and can help:

  • improve skin elasticity & hydration
  • boost muscle mass & strength
  • provide relief from joint pain
  • prevent bone loss
  • promote heart health
  • increase hair and nail strength
  • support gut health
WHAT IS A COLLAGEN SUPPLEMENT?

Although there are also several protein-rich foods we can eat to increase our collagen intake, including beef, pork skin and bone broth, we’d need to consume an enormous amount of bone broth to have any impact on our collagen levels.

High-quality collagen supplements contain animal collagen. Using a process called hydrolysation, the collagen fibres are broken down into smaller chains known as “collagen peptides” which makes it more bioavailable – i.e. easier to absorb. This is why collagen peptides are also known as hydrolysed collagen.

"Hydrolysed Collagen" is more effective because it contains a complete amino acid sequence as a collagen peptide and research shows that due to its very low molecular weight, hydrolysed collagen is absorbed at a higher level into the bloodstream and circulated throughout the body more easily than other forms of collagen.

The amino acids in collagen peptides include glycine, proline and hydroxyproline, all of which are difficult to get in large quantities from diet alone. These three amino acids are fundamental to fuelling and stimulating the production of collagen in our bodies.

WHAT IS MARINE COLLAGEN?

Unsurprisingly, Marine collagen is extracted from the bones, skin, and scales of fish. When the flesh of a fish is removed to be used as food, everything that is left, and would otherwise be discarded, is cleaned, and collagen is extracted via the process hydrolysation.

Marine collagen is therefore not suitable for those with allergies to fish.

IS MARINE COLLAGEN BETTER THAN BOVINE COLLAGEN?

Marine collagen is more sustainably produced and has less impact on the environment than for example bovine collagen which is sourced from animals (cows & pigs).

Studies that have looked at the absorption of collagen peptides found marine collagen tends to be absorbed 1.5 times better than bovine collagen due to its low molecular weight. Studies also show hydrolysed collagen seems to be well absorbed in general and can boost circulating levels of important amino acids.

Furthermore, because Marine Collagen is sourced from fish, there is a lower risk of transmissible diseases and viruses that can affect animal products such as BSE (commonly known as Mad Cow Disease) and Foot-and-Mouth Disease.

Moreover, the structure and bioavailability of collagen peptides from marine fish are quite similar to those of humans across the gastrointestinal barrier.

Marine collagen is predominantly type I, which is used in our skin, hair, nails, bones, teeth, tendons, ligaments, vascular ligature, and organs. Type I collagen accounts for 90% of the total collagen in the human body.

SCIENTIFIC BENEFITS OF COLLAGEN

Clinical studies show that HIMMENSE SHIFT's key ingredient, Type I hydrolysed marine collagen peptides, can have a beneficial effect on the appearance of skin, boost muscle mass, promote heart health, support gut health and reduce joint pain when taken daily for 12 weeks. It is thought that collagen supplements may give our natural collagen production support by triggering our body to ramp up its collagen synthesis.

Let’s delve into the science below.

MAINTAINS SKIN HEALTH & ELASTICITY

As we age, our natural collagen production begins to slow down which can result in sagging skin and the appearance of fine lines. Studies show that collagen supplements can have a beneficial effect on the appearance of skin. For example:

  • A meta-analysis published in 2023, comprising 14 randomized controlled trials involving 967 participants, found compelling results in the effectiveness of a 12-week regimen of hydrolysed collagen supplementation in improving skin hydration, elasticity, wrinkles, firmness and radiance.
  • A comprehensive meta-analysis published in 2021 in the International Journal of Dermatology, that had a total of 1,125 participants, found hydrolysed collagen supplementation showed favourable results in terms of skin hydration, elasticity and wrinkles. These findings were consistent across all 19 studies included. Based on the results, the research concluded that ingestion of hydrolysed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration.
BUILDS & STRENGTHENS MUSCLES

Collagen supplements are a source of protein. Protein contributes to the maintenance and growth of muscle mass. Protein loss occurs in muscles during and after long periods of exercise due to oxidation, inflammatory reactions, and muscle microlesions and there is robust evidence which shows that consuming protein supplements pre- and/or post-workout induces a significant rise in muscle protein synthesis.

Furthermore, several studies have shown that collagen protein supplements specifically, can lead to increased muscle strength, mass, and power. For example:

  • In a randomised controlled 12-week study, the men that took collagen supplements gained significantly more muscle mass and strength versus those that took a placebo.
  • A 2019 study in recreationally active men aged between 21-27 years showed that a combination of collagen supplements and strength training increased muscle mass and strength more than a placebo.
  • One study of 53 elderly men with sarcopenia, a loss of muscle caused by aging, found that those who took collagen daily, in addition to lifting weights three times per week for 3 months, gained significantly more muscle and lost more fat than those who only lifted weights.

During workouts, muscles absorb amino acids at a faster rate and don’t leave enough for other parts of our body. The hydrolysed marine collagen in HIMMENSE SHIFT contains 19 different amino acids including glycine and proline. Glycine is one of three amino acids that our body uses to make a compound called creatine. Studies show that creatine can increase muscle mass, strength, and exercise performance. And the amino acid proline acts as an antioxidant and helps monitor cell damage that may cause post-workout achiness.

REDUCES JOINT PAIN

Collagen helps maintain healthy cartilage, which is the rubber-like tissue that covers the surface of our joints, protecting them from wear and tear.  As we age, the amount of collagen in our body decreases so we are at an increased risk of developing conditions such as osteoarthritis. The main symptoms of osteoarthritis are joint pain and stiffness. Furthermore, high impact activities and high-intensity sports can exert stress on joints that can lead to pain and injury.

Clinical trials have shown that ingesting hydrolysed collagen stimulates the regeneration of collagen tissues, reducing joint pain and helping to prevent bone density loss. For example:

  • A meta-analysis of five randomized placebo-controlled trials involving more than 500 people with osteoarthritis found that taking collagen daily for an average of 24 weeks led to significant improvements in joint stiffness and joint pain.
  • A review of 9 studies concluded that “hydrolysed collagen has a positive therapeutic effect on osteoporosis and osteoarthritis, with a potential increase in bone mineral density, a protective effect on articular cartilage, and especially in the symptomatic relief of pain.”
  • A controlled study conducted by Penn State University found that 73 athletes who consumed hydrolysed collagen daily for 24 weeks experienced a significant decrease in joint pain while walking and at rest, compared with the group that did not take it.
HELPS MAINTAIN STRONG BONES

Bones support our body and protect our brain, heart, and other organs. Bones are mostly made of collagen, a protein that provides flexibility (toughness) to the bone structure, and calcium, a mineral that helps build and maintain healthy bones.

Collagen contributes to the formation of strong bones that are less prone to breakage, plays a role in bone tissue regeneration, and prevents bone loss. As we age, the structure of our bones changes and this results in loss of bone mass or density. Low bone mass means bones are weaker and may break or fracture more easily. Studies have shown that collagen supplementation may help improve bone mass density and slow osteoporosis. For example:

  • A randomized year-long randomized controlled study of 131 participants (with a mean age of 63 years), found that 5 grams of collagen peptides a day significantly improved bone mineral density. In addition, collagen supplementation was associated with a favourable shift in bone markers, indicating increased bone formation and reduced bone degradation.
SUPPORTS HAIR STRENGTH

When it comes to our hair, the specific protein responsible for maintaining its structure and quality is keratin. As we age and keratin reduces, hair often becomes thinner, weaker and sometimes more coarse. Marine collagen contains amino acids in a very easy to absorb form and some of these amino acids are vital for the production of keratin.

Human studies on the use of collagen supplements to increase hair growth are limited, however, there has been several studies on mice that show promising results. For example:

  • A study on mice found that the group given marine collagen peptides, experienced significantly enhanced hair regrowth versus the mice in the control groups. Based on the results, the study determined that collagen peptides could be used as food supplements for hair loss prevention as well as hair regrowth during alopecia.

Furthermore, collagen is the primary component of the dermis, which is the connective tissue layer in our bodies that contains hair follicles. Collagen contributes to the elasticity and strength of our dermis. With age, our body becomes less efficient at naturally producing collagen and replenishing cells in the dermis, and this can be one of the reasons why our hair gets thinner over time.

SUPPORTS HEART HEALTH

Collagen provides our organs and blood vessels with structural support and strength. It provides structure to our arteries, the vessels that keep blood flowing to and from our heart. Arteries play a crucial role in distributing oxygen, nutrients, and hormones throughout our body. Weak, stiff, narrow, and inflexible arteries are linked with a higher risk of cardiovascular disease, blood clots, heart attacks, and stroke.

Studies have shown collagen supplements may help reduce the risk of heart-related conditions. For example:

  • A meta-analysis published in 2022 in the British Journal of Nutrition determined that collagen supplements positively affected biomarkers related to cardiovascular disease, with randomised placebo controlled trials showing that collagen supplementation can reduce artery stiffness, decrease levels of “bad” LDL cholesterol in the body, decrease blood pressure and decrease fat mass.

If our levels of LDL “bad” cholesterol are too high, it can build up on the walls of our arteries. This build-up is also known as cholesterol plaque. This plaque can narrow our arteries and limit blood flow.

SUPPORTS GUT HEALTH

Gut health goes beyond the stomach and refers to the health of our entire digestive system, from end to end. A key feature of a healthy gut is a happy and healthy gut lining. Collagen plays a crucial role in maintaining the health of our connective tissues, including the gut lining.

The gut lining acts as a barrier, preventing harmful substances from entering the bloodstream. However, stress, poor diet, and ageing can compromise the integrity of the gut lining, leading to a condition called "leaky gut." When the gut is “leaky”, bacteria and toxins enter the bloodstream, and can cause widespread inflammation and possibly trigger a reaction from the immune system and make us sick.

Scientific studies have shown that collagen supplements can help repair the gut lining, reduce inflammation, and promote the growth of beneficial gut bacteria. For example:

  • A study published in 2022, found that a daily collagen peptide supplement for 8 weeks led to an increase in bowel movements and participants saw less bloating and an improvement in mild digestive symptoms.
  • Research shows that amino acids are essential to the health of our gut lining. Marine collagen is a source of amino acids, some of which are essential for restoring and maintaining gut integrity, specifically, glycine, glutamine and proline which support a healthy bacterial balance in our gut microbiome and facilitates a healthy gut barrier.

Scroll right/left to see the benefit and links to clinical studies.

ASHWAGANDHA

WHAT IS ASHWAGANDHA?

Ashwagandha is a plant and medicinal herb that has been used for centuries in traditional medicine, particularly in Ayurvedic medicine. Its botanical name is Withania somnifera, and it’s also known by several other names, including Indian ginseng and winter cherry. Ashwagandha, specifically the root, has adaptogenic properties meaning that it helps the body adapt to physical and mental stress. It is traditionally used to boost energy, reduce stress, support sexual function and promote physical and mental wellbeing.

The efficacy of ashwagandha in reducing stress, improving muscle strength and reducing fatigue symptoms in patients with chronic conditions has been demonstrated in scientific studies, which is why a clinical trial is underway in the UK to examine its effectiveness in promoting recovery from long COVID.

Warning: Ashwagandha is a safe supplement for most people, however, pregnant or breastfeeding women or people with thyroid conditions or autoimmune diseases (such as rheumatoid arthritis, lupus, multiple sclerosis, and type 1 diabetes) should avoid ashwagandha unless authorized by a healthcare provider.

SCIENTIFIC BENEFITS OF ASHWAGANDHA

Clinical studies have shown the ashwagandha root has several benefits including:

  • supporting sexual and reproductive function
  • maintaining sperm mobility and sperm count
  • increasing antioxidant activity
  • building muscle mass and strength
  • helping the body deal with stress and anxiety
  • maintaining emotional stability
  • supporting the onset of sleep
  • contributing to optimal mental and cognitive activity
  • promoting heart and cardiovascular health
  • maintaining optimal stamina and energy levels

Let’s delve into some of the science below.

INCREASES TESTOSTERONE & FERTILITY LEVELS

Ashwagandha has been recognised for its fertility-boosting properties for both men and women across multiple human studies. When it comes to men, several studies have shown that ashwagandha helps increase testosterone levels and significantly boosts sperm quality. For example:

  • A systematic review comprising 4 randomized controlled trials found that a 90-day treatment of ashwagandha improved sperm concentration, sperm motility, and semen volume. The participants did not experience any adverse effects.
  • In a controlled study of 75 infertile men, the group treated with ashwagandha root showed increased sperm count and motility. What’s more, the treatment led to a significant increase in testosterone levels.  The researchers also reported that the group who took the herb had increased antioxidant levels in their blood.
  • In a controlled study of 60 men, those who received ashwagandha root for male infertility overall experienced better sperm quality, a decrease in stress and higher antioxidant levels. And the treatment resulted in pregnancy in the partners of 14% of the patients.
BUILDS MUSCLE MASS & STRENGTH

Ashwagandha has been shown to increase muscle mass, reduce body fat, and increase strength. For example:

  • A double-blind, placebo-controlled clinical study of 57 male subjects (18-50 years old), showed those who took ashwagandha had significantly greater gains in muscle mass and strength, and more than doubled their reductions in body fat percentage, compared with the placebo group.
  • A study of healthy men who took 750–1,250 mg of ashwagandha root per day gained muscle strength after 30 days.
PROVIDES STRESS RELIEF

Results from several clinical trials suggest that ashwagandha extract is beneficial in reducing stress and anxiety. For example:

  • A 2021 systematic review identified seven studies investigating the efficacy of ashwagandha to treat stress and anxiety. A total of 491 adults with anxiety, were randomized to take ashwagandha or a placebo for 6 to 8 weeks. Overall, the studies found that ashwagandha significantly reduced stress and anxiety levels, reduced sleeplessness and fatigue, and reduced serum cortisol (a stress hormone) levels, compared with a placebo. The benefits appeared to be greater with doses of 500 to 600 mg/day versus lower doses.
  • A controlled study of 60 participants found those that took 600mg of ashwagandha root extract daily (vs 250mg or a placebo) experienced a statistically significant reduction in stress and anxiety and statistically significant improvement in sleep quality.

Furthermore, a 2021 review concluded that ashwagandha may also help depression and other mental health-related issues.

IMPROVES SLEEP QUALITY

Evidence suggests that ashwagandha may be an effective natural remedy to improve sleep and may especially help people with insomnia. For example:

  • A 2021 systematic review of five randomized trials involving 400 adults found that ashwagandha exhibited a significant beneficial effect on overall sleep, and participants also felt more alert when they woke up. The effects on sleep were more prominent in the subgroup of adults diagnosed with insomnia, treatment dosage ≥600 mg/day, and treatment duration ≥8 weeks.
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  • A 12-week controlled study of 50 adults aged between 65 and 85 years found those who were given 600mg of ashwagandha root extract experienced improved sleep quality and mental alertness.
ENHANCES FOCUS & MEMORY

Studies suggest the ashwagandha root also has the power to improve cognitive health and supports learning, memory and recall. For example:

  • A double-blind, controlled study of healthy male participants who took 500 mg of standardized ashwagandha root extract daily, for a period of 14 days, reported significant improvements in their reaction time and task performance, compared with men who received a placebo.
  • An 8-week placebo-controlled study in 50 adults showed that taking 300 mg of ashwagandha root extract twice daily significantly improved general memory, task performance, and attention.
SUPPORTS HEART HEALTH

VO2 max is the maximum amount of oxygen a person can use during intense activity. It’s a measurement of heart and lung fitness. Low VO2 max is associated with increased mortality risk, while higher VO2 max is associated with better endurance and overall fitness, and a lower risk of heart disease. Research has shown that ashwagandha can increase VO2 max levels and have beneficial effects on athletic performance by improving heart and lung capacity. For example:

  • A systematic review of 12 controlled studies involving 615 healthy adults found evidence that ashwagandha supplementation (varying from 120mg-1,250mg per day) enhanced physical performance (strength/power, cardiorespiratory fitness and fatigue/recovery).
  • A systematic review that looked at four controlled studies involving 161 adults, found that those taking ashwagandha supplements (varying from 300mg-1000mg per day) significantly enhanced maximum oxygen consumption (VO2 max).

Ashwagandha may also help reduce the risk of heart disease by decreasing cholesterol and triglyceride levels. For example:

  • A study in rats found that ashwagandha lowered total cholesterol and triglyceride levels by 53% and nearly 45%, respectively.

While controlled human studies have reported less dramatic results, they have observed some impressive improvements in these markers.

MAINTAINS ENERGY & STAMINA

Ashwagandha helps to maintain optimal stamina and feelings of energy and vitality. For example:

  • Ashwagandha helps improve the body’s resistance to stress. Stress and anxiety can contribute to feelings of fatigue and low energy. A 2021 systematic review of seven studies involving 491 adults found that ashwagandha significantly reduced stress and anxiety levels, and reduced sleeplessness and fatigue compared with placebo.
  • Ashwagandha helps support the onset of sleep. Lack of sleep and poor quality of sleep can also contribute to feelings of fatigue and low energy. A 2021 systematic review of five randomized trials involving 400 adults found that ashwagandha had a significant positive effect on overall sleep quality, and participants also felt more alert when they woke up.
  • Ashwagandha can improve physical performance (muscle strength, VO2 max, muscle fatigue, tiredness and recovery). A meta-analysis of studies involving 615 healthy adults found that there is direct evidence suggesting that Ashwagandha supplementation has a positive effect on physical performance, including fatigue/recovery related variables, when compared to a placebo or control group.
REDUCES BLOOD SUGAR LEVELS

Some studies have found ashwagandha to be helpful in reducing blood glucose levels. For example:

  • A review of 24 studies, including 5 clinical studies in people with diabetes, found that treatment with ashwagandha significantly reduced blood sugar, haemoglobin A1c (HbA1c), insulin, blood lipids, and oxidative stress markers.
FIGHTS INFECTION & DISEASE

A review published in 2020 summarizes the therapeutic potential of ashwagandha to treat diseases associated with inflammation in the body, such as cardiovascular, pulmonary, and autoimmune diseases and diabetes, cancers, and neurodegenerative diseases. This is because it contains withaferin A, a natural bioactive molecule that has anti-inflammatory and anticancer properties. For example:

  • A randomized, double-blind, placebo-controlled trial conducted to evaluate the effect of ashwagandha extract on the immune system of healthy participants showed that, it significantly increased the activity of natural killer cells, which are immune cells that fight infection and help us stay healthy, and it decreased markers of inflammation.
  • A review of the role of ashwagandha in cancer prevention found that the plant is highly effective in combating various types of cancers including breast, lung, colon, prostate, skin and blood cancer.
  • Evidence presented in a 2021 review of 77 clinical trials showed that ashwagandha extract for a period of 8 to 12 weeks can be useful in managing arthritis symptoms in patients. 
  • Some medical studies suggest that ashwagandha may also have applications in the treatment of COVID-19 as the adaptogen has been shown to reduce symptoms of similar conditions. In fact, researchers at the London School of Hygiene and Tropical Medicine are currently conducting a clinical trial to assess whether ashwagandha, the traditional Indian herbal medicine, can promote recovery from Long COVID.

Scroll right/left to see the benefit and links to clinical studies.

SELENIUM

WHAT IS SELENIUM GOOD FOR?

Selenium is an essential trace mineral that our bodies need to function. It contributes to:

  • normal spermatogenesis (the production of sperm)
  • the maintenance of normal hair and nails
  • normal thyroid function
  • the normal function of the immune system
  • the protection of cells from oxidative stress

Good sources of selenium include brazil nuts, fish, meat and eggs.

Warning: Whilst selenium is essential for good health, getting too much can be dangerous. For example, too much selenium causes selenosis, a condition that, in its mildest form, can lead to loss of hair and nails. The NHS advise that an intake of 350μg or less a day of selenium is unlikely to cause any harm. Himmense SHIFT contains 55μg of Selenium (100% NRV).

SCIENTIFIC BENEFITS OF SELENIUM

Selenium plays a critical role in fertility and important processes in our body, including our thyroid function. It also helps protect our body from damage caused by oxidative stress and helps the immune system work properly. Scientific studies show that selenium deficiency may contribute to hair loss, a weakened immune system, male infertility, age-related mental decline, increased cancer risk, and heart disease.

Let’s delve into some of the science below:

ENHANCES FERTILITY

Selenium is critical for human health and reproductive functions. Studies have indicated that selenium levels outside the recommended range could be a factor in both male and female fertility, and that selenium supplements can help to improve semen quality at the same time as lowering the risk of miscarriage. For example:

  • A scientific review published in 2021 found selenium supplementation can significantly improve sperm fertility parameters.
SUPPORTS THYROID FUNCTION

The fact that there’s more selenium in thyroid tissue than in any other organ in the human body, tells us something about the influential role this mineral plays in the proper functioning of our thyroid gland. And a healthy thyroid gland is important, as it regulates our metabolism and controls growth and development. For example, selenium is essential for the production of the thyroid hormones that help to regulate hair growth and strong evidence links thyroid dysfunction to hair loss. Furthermore, some clinical studies have shown that lack of selenium will increase the prevalence thyroid dysfunction and several kinds of thyroid diseases. For example:

  • A study including over 6,000 people found that low levels of selenium were associated with abnormal thyroid function.
  • A 2021 review of autoimmune thyroiditis (AITD) and Hypothyroidism clearly identified selenium deficiency as an important risk factor for Autoimmune thyroid diseases (AITD).
BOOSTS THE IMMUNE SYSTEM

Selenium is crucial for the health and proper functioning of our immune system which keeps our body healthy by identifying and fighting off potential threats including bacteria, viruses, and parasites. Selenium deficiency has long been recognized to negatively impact immune cells, thereby increasing the risk of bacterial and viral infections. For example:

  • A review comparing results from a wide variety of studies showed that selenium deficiency harms immune cell function and may lead to a slower immune response.
  • A review analysing data from epidemiologic studies and intervention trials showed that selenium supplements help boost the immune systems of people with influenza, tuberculosis, HIV and hepatitis C.
  • A review of studies found an association with selenium deficiency and an increased risk of death and disease progression in people with HIV, while selenium supplements were shown to lead to fewer hospitalizations and an improvement in symptoms for HIV patients.
REDUCES RISK OF DISEASE

Selenium is a powerful antioxidant that protects our cells against oxidative stress and helps defend our body from chronic conditions. Oxidative stress is caused by an excess of free radicals in the body. Smoking, alcohol use, and stress can cause an excess of free radicals. This leads to oxidative stress, which damages healthy cells. Antioxidants like selenium help reduce oxidative stress by keeping free radical numbers in check to lessen our risk of diseases, including cancer, diabetes, Alzheimer’s disease, mental disorders, cardiovascular disorders, fertility impairments, inflammation, and infections. They work by neutralizing excess free radicals and protecting cells from damage caused by oxidative stress. For example:

  • A controlled study including 465 coronary artery disease patients found selenium supplementation leads to an increase in antioxidative glutathione peroxidase 1 (GPx1) activity.
SUPPORTS HEART HEALTH

Oxidative stress and inflammation have been linked to atherosclerosis, or the build-up of plaque in arteries. Atherosclerosis is where our arteries become narrowed, making it difficult for blood to flow through them. It increases the risk of heart attack and stroke. Studies suggest selenium may help keep our heart healthy by reducing inflammation and oxidative stress in our body. For example:

  • A meta-analysis of 25 observational studies found a 50% increase in blood selenium levels was associated with a 24% reduction in the risk of heart disease.
  • A review of 16 controlled studies, involving more than 400,000 people with heart disease, showed taking selenium supplements decreased levels of the inflammatory marker C-reactive protein (CRP) — one of the main risk factors for heart disease.
DECREASES CANCER RISK

Research suggests that higher blood levels of selenium may protect against certain cancers, while supplementing with selenium may help improve quality of life in people undergoing radiation therapy. For example:

  • A review of 69 studies that included over 350,000 people, found that having a high blood level of selenium was associated with a lower risk of certain types of cancer, including breast, lung, and prostate cancers.
  • A review of 16 clinical studies on selenium and radiotherapy, which included 1303 cancer patients, concluded that selenium supplements improved the general condition of patients, improved their quality of life and reduced the side effects of radiotherapy. Furthermore, selenium supplementation did not reduce the effectiveness of radiotherapy or cause any toxicity.
PROTECTS Cognitive health

The leading cause of death in 2022 in the UK was dementia and Alzheimer’s. Oxidative stress is believed to be involved in both the onset and progression of neurological diseases like Alzheimer’s, multiple sclerosis, and Parkinson’s. Studies show that selenium may help prevent mental decline and improve memory loss. For example:

  • A meta-analysis of 6 studies found that selenium supplementation alleviated some of the symptoms of Alzheimer’s disease and Mild Cognitive Impairment.
  • A study analysing metals in the progression of Alzheimer’s disease found patients with Alzheimer’s disease had lower blood levels of selenium.
  • A controlled study examining the long-term effects of antioxidant supplementation on the cognitive performance of 4447 participants found that subjects receiving active antioxidant supplementation (including 100μg of Selenium) had better episodic memory scores.
REDUCES ASTHMA SYMPTOMS

Asthma is associated with increased inflammation, oxidative stress and abnormal immune system function. Some studies suggest that selenium may help reduce asthma-related symptoms due to its role in regulating excessive immune responses and chronic inflammation. For example:

  • A controlled study showed that asthmatic patients had significantly lower concentration levels of blood selenium compared with healthy subjects.
  • A study found that giving people with asthma 200μg of selenium per day reduced their use of the corticosteroid medications used to control their symptoms.

Scroll right/left to see the benefit and links to clinical studies.

VITAMIN C

WHAT IS VITAMIN C GOOD FOR?

Vitamin C, also known as ascorbic acid, is a vital nutrient for health, it contributes to:

  • normal collagen formation for the normal function of skin, cartilage, bones, teeth, gums and blood vessels
  • normal function of the immune system
  • protection of cells against damage caused by oxidative stress
  • normal functioning of the nervous system
  • normal psychological function
  • normal energy-yielding metabolism
  • the reduction of tiredness and fatigue

Vitamin C also helps the body absorb iron, a mineral our body uses to make red blood cells which carry oxygen to all parts of our body.

Furthermore, vitamin C plays a significant role in healing wounds.

A vitamin C deficiency can lead to scurvy, gum and dental problems, joint and muscle pain, anaemia, tiredness and problems fighting infections.

Good sources of vitamin C include citrus fruit, peppers, strawberries, blackcurrants, broccoli, and potatoes.

Because vitamin C is a water-soluble vitamin, it cannot be stored in the body and must be obtained daily from diet or supplements.

SCIENTIFIC BENEFITS OF VITAMIN C

Vitamin C is involved in many body functions, including formation of collagen, absorption of iron, the proper functioning of the immune system, protection of cells, wound healing, and the maintenance of healthy skin, cartilage, bones, and teeth. Furthermore, scientific studies show that Vitamin C can help reduce dementia risk, support sexual function, guard against chronic disease, manage high blood pressure and prevent anaemia.

Let’s delve into some of the science below:

STIMULATES COLLAGEN PRODUCTION

Vitamin C contributes to normal collagen formation. Collagen is a protein that is required for the health and repair of various tissues in the body including skin, bone, cartilage, ligaments and tendons, blood vessels, gums and teeth. In fact, the body cannot produce collagen without vitamin C. Studies have shown that taking vitamin C orally increases collagen production. For example:

  • Studies have shown that vitamin C stimulates collagen synthesis and plays a significant role in the maintenance of healthy skin, protection against UV-damage and the healing of wounds.
  • Studies have shown when we are deficient in vitamin C, the collagen produced by fibroblasts is unstable, so tissue repair is less efficient, and wounds take longer to heal.
  • A systematic review demonstrated that vitamin C has the potential to increase type I collagen synthesis, accelerate bone healing after a fracture, and reduce oxidative stress parameters.
  • A study of 1,785 subjects found that those who consumed the highest levels of vitamin C showed significantly less damage to the cartilage compared to those with lower intakes.
  • A study found that Periodontitis (gum disease) is associated with low concentrations of vitamin C.
SUPPORTS THE IMMUNE SYSTEM

It’s well established that vitamin C contributes to the normal function of the immune system. For example:

  • A review found vitamin C supports the immune system by protecting against oxidative stress, aids in microbial killing and decreases the potential for tissue damage. The review also found that vitamin C deficiency results in impaired immunity and higher susceptibility to infections.
  • A meta-analysis found that Vitamin C supplements could help us recover more quickly from a common cold.
REDUCES RISK OF DISEASE

Vitamin C contributes to the protection of cells from oxidative stress. Oxidative stress is caused by an excess of free radicals, which are volatile and harmful substances in the body that cause damage to cells and tissues. Antioxidants, like vitamin C, help reduce oxidative stress by keeping free radical numbers in check to lessen our risk of chronic diseases, including cancer, Alzheimer’s, heart disease and infections. They work by neutralizing excess free radicals and protecting cells from damage caused by oxidative stress. For example:

  • Studies show that low Vitamin C levels may have a role in cancer, diabetes and neurological disorders.
  • A UK study found that the risk of stroke in those with highest intake of vitamin C was only half that of subjects with the lowest intake.
  • An analysis of 9 studies with a combined 293,172 participants found that after 10 years, people who took at least 700 mg of vitamin C daily had a 25% lower risk of heart disease than those who did not take a vitamin C supplement.
  • A meta-analysis of 29 studies found that taking a vitamin C supplement reduced systolic blood pressure (the upper value) by 3.8 mmHg and diastolic blood pressure (the lower value) by 1.5 mmHg, on average, in healthy adults. In adults with high blood pressure, vitamin C supplements reduced systolic blood pressure by 4.9 mmHg and diastolic blood pressure by 1.7 mmHg, on average.

Furthermore, vitamin C, contributes to regenerating the antioxidant capacity of vitamin E.

SUPPORTS SEXUAL FUNCTION

Oxidative stress reduces testosterone synthesis. Vitamin C is a powerful antioxidant which protects the body against oxidative stress and can improve hormone profiles. For example:

  • A study involving over 300 infertile men found that ascorbic acid (vitamin C) is associated with higher testosterone levels and improved androgenic status in infertile males.

Research also suggests that vitamin C might play a role in certain biochemical pathways that support erectile function. For example:

  • A review noted that vitamin C is one of several vitamins and minerals that support the biochemical pathway that leads to the release of nitric oxide. Nitric oxide (NO) is generally viewed as the principal agent responsible for relaxing the tissue inside the penis and allowing blood to flow in and create an erection.
PROTECTS BRAIN FUNCTION

Studies suggest that oxidative stress and inflammation near the brain, spine, and nerves (altogether known as the central nervous system) can increase the risk of dementia. Vitamin C contributes to the protection of cells from oxidative stress and low vitamin C levels have been linked to an increased risk of memory and thinking disorders like dementia, while a high intake of vitamin C has been shown to have a protective effect on thinking and memory as we age. For example:

  • A systematic review found higher vitamin C concentrations in cognitively intact study participants compared with those with the cognitively impaired participants (i.e. those with dementia including Alzheimer’s disease).
SUPPORTS ENERGY-YIELDING MATABOLISM

Vitamin C helps convert the food and drinks we consume into energy and also helps us to absorb other vitamins and minerals to keep our bodies healthy. For example:

  • A review of biochemical and clinical evidence found that insufficient vitamin C can be responsible for weakness.
REDUCES TIREDENESS & FATIGUE

Vitamin C helps reduce tiredness and fatigue and it also helps the body absorb iron. Symptoms of iron deficiency include tiredness. Studies have found links between insufficient vitamin C and fatigue. For example:

  • A randomised trial involving 141 office workers aged 20–49 years who received 10g vitamin C or a placebo in one intravenous injection found that fatigue scores 2 h and 1 day after intervention were significantly lower in the vitamin C-treated group and especially in those who had the lowest baseline serum vitamin C.
  • A placebo-controlled study involving 20 adults over 4 weeks found that general fatigue scores and ratings of perceived exertion during moderate exercise were significantly decreased in the subjects receiving 500mg of vitamin C.
  • A UK study involving more than 15,000 adults found that the quartile with the lowest level of vitamin C had significantly increased odds of having a poor physical health score, a poor bodily pain score, poor self-reported general health and poor vitality score.
  • Several recent studies have indicated that intravenous (IV) vitamin C in patients who have cancer and chemotherapy-related symptoms, such as fatigue, insomnia, loss of appetite, nausea, and pain, have led to improvements in physical, cognitive, emotional, and social functioning, as well as an improvement in overall health.
IMPROVES IRON ABSORPTION

Iron is a mineral essential for making red blood cells that transport oxygen throughout the body. Symptoms of iron deficiency anaemia include tiredness, a lack of energy and pale skin. Vitamin C supplements can help the body absorb iron. For example:

  • A scientific algorithm shows that consuming 100 mg of vitamin C may improve iron absorption by 67%.

Scroll right/left to see the benefit and links to clinical studies.

VITAMIN D

WHAT IS VITAMIN D GOOD FOR?

Vitamin D - sometimes known as the “sunshine vitamin” due to its ability to be absorbed by the body through sunlight – contributes to:

  • the normal absorption/utilisation of calcium and phosphorus
  • normal blood calcium concentrations
  • the maintenance of normal bones and teeth
  • the maintenance of normal muscle function
  • the normal function of the immune system
  • the process of cell division

Vitamin D also helps to reduce the risk of falling associated with postural instability and muscle weakness. Falling is a risk factor for bone fractures among men and women 60 years of age and older.

There are three ways that the body can get vitamin D:

  • from direct sunlight on the skin when outdoors
  • from a small number of foods including oily fish, red meat, liver, egg yolks and fortified foods (but it's difficult to get enough vitamin D from food alone)
  • from supplements

In the U.K., between October and early March we do not make enough vitamin D from sunlight and since it is difficult for people to get enough vitamin D from food alone, the NHS advise everyone should consider taking a daily supplement containing 10 micrograms (400 IU) of vitamin D during the autumn and winter.

Furthermore, the Department of Health and Social Care recommends that we take a daily supplement containing 10 micrograms of vitamin D every day throughout the year if we have dark skin (as the higher the levels of melanin, the less vitamin D the skin can absorb) OR are not often outdoors OR usually wear clothes that cover up most of our skin when outdoors.

SCIENTIFIC BENEFITS OF VITAMIN D

Vitamin D has several important functions. Perhaps the most vital are supporting the immune system and regulating the absorption of calcium and phosphorus, which are needed to keep bones, teeth, and muscles healthy. Furthermore, researchers have found a link between vitamin D deficiency and fatigue, depression, chronic diseases and male sexual function.

Let’s delve into some of the science below:

KEEPS BONES STRONG

Vitamin D helps our body absorb and use calcium and phosphorus, which keeps our bones (and teeth) strong. It is well established that low vitamin D levels can lead to bone weakness and increase our risk of osteoporosis and broken bones. And a severe shortage of vitamin D causes rickets and osteomalacia (soft bones). For example:

  • A review showed that inadequate vitamin D intakes over long periods of time can lead to decreased calcium absorption, bone demineralization, weakened bones, increased risk of fractures and ultimately the development of osteopenia and osteoporosis.
  • A controlled trial of 100,000 IU oral Vitamin D supplementation, involving more than 2,500 adults, reported a 33% lower rate for fracture and a 22% lower rate for first fracture at any site compared to a placebo.
  • A meta-analysis of seven randomised controlled trials involving older persons (>or=60) concluded vitamin D supplementation in the range of 700-800 IU/d reduced the risk of hip/non-vertebral fractures by 25%.
  • A study reported a significant benefit in bone mineral density after only five weeks in participants with impaired vitamin D status and osteoporosis/ osteopenia.
KEEPS TEETH & GUMS HEALTHY

Vitamin D plays a key role in absorbing and retaining calcium and phosphorous for tooth mineralization. When our vitamin D levels are unregulated, it weakens our teeth, making us highly susceptible to cavities, fractures, and decay. Researchers have linked a vitamin D deficiency to two main oral issues: Tooth Decay and Periodontitis (gum disease). For example:

  • A comprehensive review of studies found vitamin D deficiency is highly implicated with oral diseases and has been linked with a higher risk of tooth defects, caries, periodontitis and oral treatments failure.
MAINTAINS MUSCLE FUNCTION

Vitamin D contributes to the maintenance of normal muscle function. Studies have demonstrated that vitamin D supplementation can improve muscle strength which in turn contributes to a decrease in incidence of falls, one of the largest contributors to fracture incidence. For example:

  • In vitro evidence demonstrated that vitamin D can increase protein synthesis and cellular growth in muscle cells with an increase in size and number of type 2 muscle fibres, which are of particular importance as these are the first muscle fibres recruited when falling.
  • An study, involving more than 4000 older adults (>or=60) reported vitamin D plasma concentrations in the range of 40-90nmol/L was associated with improved musculoskeletal function versus serum concentrations <40nmol/L.
  • A study has suggested that impaired muscle function in vitamin D deficient subjects could be present even before indications of bone disease have been recognised.
BOOSTS ENERGY

Vitamin D plays a role in reducing fatigue and boosting energy levels because it aids the function of the mitochondria within the body’s cells, which is responsible for creating energy. Research has shown that Vitamin D deficiency is associated with fatigue. For example:

  • A study found that patients with vitamin D deficiency who experienced symptoms of muscle fatigue, improved their muscle efficiency and recovery rates when their vitamin D levels were improved. Furthermore, all patients reported an improvement in symptoms of fatigue after having taken the supplements.
  • A controlled study involving 120 adults found 30 days of vitamin D treatment significantly improved fatigue in otherwise healthy persons with vitamin D deficiency.
SUPPORTS THE IMMUNE SYSTEM

Vitamin D contributes to the normal function of the immune system. Studies show that people who do not have adequate vitamin D levels might be at increased risk of infections and autoimmune diseases. For example:

  • A review of 25 studies involving more than 11,000 participants found that vitamin D supplementation helped reduce the risk of respiratory tract infections (such as the common cold, bronchitis, and pneumonia). Supplementation was even more beneficial for people with low or very low levels of vitamin D.
  • A review found a clear link between vitamin D deficiency and many infections and infectious processes.
REDUCES RISK OF DISEASE

Studies show that vitamin D may play a role in improving our resistance to certain diseases. For example:

  • A large study found that high circulating levels of vitamin D are associated with a lower risk of multiple sclerosis.
  • A meta-analysis including 81 randomized clinical trials, highlighted the ability of vitamin D supplementation to improve some cardiovascular risk factors including elevated blood pressure, hyperparathyroidism, dyslipidemia, and inflammation.
  • A review found that several studies have demonstrated a strong association between vitamin D insufficiency and risk of cardiovascular disease, risk of diabetes and metabolic syndrome.
  • A review found that vitamin D supplements may help treat hypertension and high blood pressure.
  • A study found that vitamin D supplementation during the winter may reduce the incidence of influenza A.
  • A large study found a beneficial role for vitamin D intake in reducing the risk of type 2 diabetes.
  • Studies have found that higher vitamin D levels have been consistently associated with reduced risks of certain cancers.
  • A systematic review and meta-analysis of randomized, controlled trials, found that supplementing with vitamin D may protect against negative outcomes related to COVID-19.
REGULATES MOOD

Research has shown that vitamin D might play an important role in regulating mood and fighting off depression. For example:

  • A review of 25 trials involving more than 7,500 people found that those experiencing negative emotions who received vitamin D supplements noticed an improvement in symptoms. The meta-analysis concluded that patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation.
  • A study identified low vitamin D levels as a risk factor for more severe fibromyalgia symptoms, anxiety, and depression.
SUPPORTS SEXUAL FUNCTION

Although research into the effects of vitamin D on sexual performance is limited, some studies have found a link between vitamin D deficiency and male sexual function. For example:

  • A study involving 260 men clearly demonstrates a direct and positive relationship between vitamin D levels and overall semen quality, male reproductive potential and testosterone levels.
  • A meta-analysis of 8 studies involving 4055 patients found that vitamin D deficiency may be associated with severe forms of erectile dysfunction.
  • A small study investigating sexual function and depression symptoms in young men, found that men with vitamin D deficiency or insufficiency had lower levels of erectile function than men with normal vitamin D levels.

Scroll right/left to see the benefit and links to clinical studies.

VITAMIN B12

WHAT IS VITAMIN B12 GOOD FOR?

Vitamin B12, also known as cobalamin, is arguably the most important of the eight B vitamins and contributes to:

  • normal energy-yielding metabolism
  • normal red blood cell formation
  • the reduction of tiredness and fatigue
  • normal functioning of the nervous system
  • normal psychological function
  • normal function of the immune system
  • normal homocysteine metabolism

Vitamin B12 also has a role in the process of cell division.

Good sources of vitamin B12 are meat, fish, milk, cheese and eggs.

Because vitamin B12 is a water-soluble vitamin, it cannot be stored in the body and must be obtained daily from diet or supplements.

Symptoms of deficiency include anaemia, fatigue, muscle weakness, depression, disturbed vision, and dementia. Those at risk of vitamin B12 deficiency include: older adults; people on a strict vegan diet; people with gastrointestinal disorders, such as Crohn’s disease or celiac disease; those who have had gastrointestinal surgeries, such as bariatric surgery or bowel resection surgery; and those who take metformin for blood sugar control.

SCIENTIFIC BENEFITS OF VITAMIN B12

Vitamin B12 plays key roles in converting food into energy, fighting fatigue, keeping the brain and nervous system functioning properly, regulating our immune system and mood, and controlling levels of the amino acid homocysteine, elevated levels of which are associated with numerous diseases. Researchers have also found a link between B12 deficiency and male sexual function.

Let’s delve into some of the science below:

MAINTAINS ENERGY LEVELS

One of the most common early signs of vitamin B12 deficiency is fatigue or lack of energy. Vitamin B12 helps maintain our energy levels by contributing to energy-yielding metabolism and red blood cell formation. For example:

  • Research shows that B12, along with all the other B vitamins, are involved in the production of energy.
  • Research shows B12 is vital for normal red blood cell formation which is critical for efficiently transporting oxygen throughout the body, and a chronic deficiency in vitamin B12 can trigger anaemia, symptoms of which include fatigue and weakness.
  • A study showed that deficiencies in B12 can result in diminished energy and exercise tolerance, together with fatigue and shortness of breath. These hematologic symptoms regress and disappear with B12 supplementation.
HELPS PREVENT ANAEMIA

Vitamin B12 plays a vital role in helping our body produce red blood cells. A deficiency in B12 can lead to anaemia (a condition that develops when the body produces a lower-than-normal amount of healthy red blood cells). Anaemia results in the body not getting enough oxygen-rich blood, which can result in symptoms including fatigue and weakness. For example:

  • Studies have shown that among patients with anaemia up to 20% were due to a B12 deficiency.
SUPPORTS SEXUAL FUNCTION

Research has shown that when our body lacks enough B12, testosterone levels can drop significantly and that vitamin B12 also impacts testicular health and sperm quality, as well as energy levels and stamina. For example:

  • A clinical study found that 76% of men presenting with chronic testicular pain were deemed deficient for testosterone and B12 levels. Of those that elected to receive B12 and/or testosterone replacement 65% reported significant improvement of symptoms.
  • A meta-analysis concluded that mainstream published work demonstrates the positive effects of vitamin B12 on semen quality: first, by increasing sperm count, and by enhancing sperm motility and reducing sperm DNA damage.

Furthermore, researchers believe vitamin B12 supplements may improve erectile function. This is because vitamin B12 is involved in the breakdown of homocysteine – an amino acid which can damage artery linings when allowed to build up in the circulation. Hardening and furring up of the arteries (atherosclerosis) is a leading cause of erectile difficulties in older males and in those with diabetes. For example:

  • A systemic review and meta-analysis of nine studies including 1,320 men found that the men with erectile dysfunction (ED) were approximately twice as likely to have elevated levels of homocysteine.
  • A study involving 691 men who identified as having erectile dysfunction (ED), found that age, homocysteine (Hcy) and vitamin B12 levels were the main determinants in ED. Hcy levels were increased in men over 45 with ED, but vitamin B12 was decreased in men under 45 with ED.
MAINTAINS BRAIN FUNCTION

The body needs vitamin B12 for neurological and psychological function. Researchers have found an association between Vitamin B12 deficiency and neurocognitive disorders. For example:

  • A study in people with early-stage dementia showed that a combination of vitamin B12 and omega-3 fatty acid supplements slowed mental decline.
  • A study found that even vitamin B12 levels on the low side of the normal range are associated with poorer memory performance.
  • A study involving 202 patients with minimal cognitive impairment found that 84% reported marked symptomatic improvement after B12 replacement.
  • A study involving 3136 adults followed for 20 years from age 18 to 30, found that that those in the highest quintile of dietary vitamin B12 intake at baseline (median 8.7 µg/day) had better psychomotor speed 20 to 25 years later versus those with the lowest dietary intake of B12 (median 2.2 µg/day).
  • A study using functional biomarkers of vitamin B12 status showed a trend towards associations between poor vitamin B12 status in an ageing population and faster cognitive decline and risk of Alzheimer’s disease.
IMPROVES MOOD

The body needs vitamin B12 for normal psychological function. B12 acts as a cofactor in synthesis of neurotransmitters such as serotonin and dopamine, thus B12 deficiency affects mood, emotions and sleeping. Studies support the use of vitamin B12 supplements for improving symptoms of depression in people with a vitamin B12 deficiency. For example:

  • A review of studies concluded that supplementation of Vitamin B12 early enough can delay the onset of depression.
  • A controlled study in people with depression and low vitamin B12 levels found that those who received both antidepressants and vitamin B12 were more likely to show improved depressive symptoms, compared to those treated with antidepressants alone.
  • A study involving 3884 elderly people with depressive disorders found that those with vitamin B12 deficiency were almost 70% more likely to experience depression than those with normal vitamin B12 status.
REDUCES RISK OF DISEASE

Vitamin B12 is vital for proper functioning of the immune system and a cofactor in controlling levels of the amino acid homocysteine. Studies show that a deficiency in B12 and/or elevated levels of homocysteine has been associated with many diseases. For example:

  • A review of 9 studies, found that researchers reported deficiency in B12 was associated with viral diseases.
  • A comprehensive review of evidence found that the consumption of a healthy diet containing vitamin B12 sources, and especially supplementation with methylcobalamin and cyanocobalamin, are promising alternatives as adjuvants in the treatment of COVID-19, especially in patients with B12 deficiency or deficiency risk.
  • Evidence shows a deficiency in B12 can lead to an increased risk of hyperhomocysteinemia (elevated levels of homocysteine in the blood) which has been regarded as a marker of cardiovascular disease and a definite risk factor for many other diseases, including neurodegenerative diseases, auto immune disorders, diabetes, osteoporosis, age-related macular degeneration and cancer.
  • A controlled study showed that vitamin B12 helps decrease homocysteine levels, a type of amino acid that is associated with an increased risk of stroke.
  • A meta-analysis found that supplementing with vitamin B12 may lower homocysteine levels which has been associated with an increased risk of age-related macular degeneration (an eye disease that mainly affects central vision).
  • A review concluded that disturbed homocysteine metabolism is associated with many forms of human cancer.
  • A study in more than 2,500 adults showed that people with a vitamin B12 deficiency had lower than normal bone mineral density which can become delicate and fragile over time, leading to an increased risk of osteoporosis.
MAINTAINS HEALTHY SKIN, HAIR AND NAILS

Adequate levels of Vitamin B12 are needed to promote healthy hair, skin and nails given its role in the process of cell division. For example:

  • A review found that that abnormal vitamin B12 levels can cause various dermatological symptoms including hyperpigmentation, acne, hair changes, nail discolouration, vitiligo and angular stomatitis (inflamed and cracked mouth corners).

Scroll right/left to see the benefit and links to clinical studies.

VITAMIN B6

WHAT IS VITAMIN B6 GOOD FOR?

Vitamin B6, also known as pyridoxine, is one of the eight B vitamins. It contributes to:

  • normal energy-yielding metabolism
  • normal protein and glycogen metabolism
  • normal red blood cell formation
  • the reduction of tiredness and fatigue
  • normal functioning of the nervous system
  • normal psychological function
  • the regulation of hormonal activity
  • the normal function of the immune system
  • normal homocysteine metabolism
  • normal cysteine synthesis

Good sources of vitamin B6 are protein-rich foods such as pork, poultry, fish, peanuts, soya beans, oats, bananas, and milk.

Because vitamin B6 is a water-soluble vitamin, it cannot be stored in the body and must be obtained daily from diet or supplements.

SCIENTIFIC BENEFITS OF VITAMIN B6

Vitamin B6 plays key roles in converting food into energy, keeping the brain and nervous system functioning properly and production of haemoglobin, the protein in blood that carries oxygen throughout the body. It also helps the body make the hormones serotonin (which regulates mood) and norepinephrine (which helps our bodies cope with stress). Furthermore, a growing body of research suggests that vitamin B6 may play a role in testosterone production and reducing our risk of certain diseases.

Let’s delve into some of the science below:

MAINTAINS ENERGY LEVELS

Vitamin B6 helps maintain our energy levels by contributing to energy-yielding metabolism, red blood cell formation and the reduction of tiredness and fatigue. For example:

  • Research shows that B6 is essential for the production of energy, specifically for the chemical breakdown of glycogen – which gives our bodies the glucose it needs for physical activity. Glucose, along with fat and protein is one of the body's primary fuel sources.
  • Research shows vitamin B6 is vital for normal red blood cell formation which is critical for efficiently transporting oxygen throughout the body. When red blood cells reach tissues that need oxygen, the oxygen is released from the haemoglobin present in red blood cells and diffuses into the tissues where it is used to make energy.
  • Research shows that chronic deficiency in vitamin B6 may trigger microcytic anaemia, symptoms of which include fatigue and weakness.
HELPS PREVENTS ANAEMIA

Vitamin B6 plays a vital role in helping our body produce red blood cells. Studies have linked low levels of vitamin B6 with anaemia (a condition that develops when our blood produces a lower-than-normal amount of healthy red blood cells). Anaemia results in the body not getting enough oxygen-rich blood, which can result in fatigue and weakness. For example:

  • One study found that taking 75 mg of vitamin B6 daily during pregnancy decreased symptoms of anaemia in 56 pregnant women who were unresponsive to treatment with iron.
IMPROVES MOOD

Vitamin B6 contributes to normal psychological function and plays an important role in mood regulation because it is necessary for creating serotonin, dopamine and gamma-aminobutyric acid (GABA) which are neurotransmitters that regulate emotions. For example:

  • A controlled study found that vitamin B6 actively helps reduce feelings of anxiety and depression.
  • A study involving 140 participants showed that depressive symptoms are associated with low levels of vitamin B6, especially in older adults who are at high risk for B vitamin deficiency.
  • A study in 250 older adults found that deficient blood levels of vitamin B6 doubled the likelihood of depression.
MAINTAINS BRAIN FUNCTION

A growing body of research suggests that Vitamin B6 may prevent a decline in brain function by regulating homocysteine levels that have been associated with Alzheimer’s disease and memory impairments. For example:

  • A study in 156 adults with high homocysteine levels and mild cognitive impairment found that taking high doses of B6, B12 and folate (B9) decreased homocysteine and reduced wasting in some regions of the brain that are vulnerable to Alzheimer’s.
  • Research shows that a deficiency in B6 may lead to a lack of methionine synthesis that leads to the accumulation of homocysteine, which is a suspected risk factor for cognitive dysfunction and dementia.
SUPPORTS SEXUAL FUNCTION

Vitamin B6 contributes to the regulation of hormonal activity including maintaining healthy levels of testosterone, which plays a role in sexual health and function. Furthermore, vitamin B6 is essential for the production of neurotransmitters, which are chemicals that transmit signals between nerve cells. These neurotransmitters play a crucial role in sexual arousal and response. Researchers believe that vitamin B6’s effect on sexual function is due to its impact on neurotransmitters and hormones. For example:

  • Some fundamental research studies have found that vitamin B6 has a role to play in the production of testosterone.

Furthermore, researchers believe vitamin B6 supplements may improve erectile function. This is because vitamin B6 is involved in the breakdown of homocysteine – an amino acid which can damage artery linings when allowed to build up in the circulation. Hardening and furring up of the arteries (atherosclerosis) is a leading cause of erectile difficulties in older males and in those with diabetes. For example:

  • A systemic review and meta-analysis of nine studies including 1,320 men found that the men with erectile dysfunction (ED) were approximately twice as likely to have elevated levels of homocysteine.
STRENGTHENS THE IMMUNE SYSTEM

Vitamin B6 participates in the functioning of the entire immune system and research shows adequate levels of B6 help prevent various diseases. For example:

  • A study summarised the available evidence on the role of vitamin B6 in alleviating the symptoms of COVID-19 infection and complications such as diabetes, hypertension and heart disease after Covid-19.
  • A study found B6 deficiency leads to a decrease in immunity, including the formation of serum antibodies, decreased production of IL-2, and increased IL-4. This is relevant because there is an inverse relationship between vitamin B6 and IL-6 and TNF-α levels in conditions of chronic inflammation. And research has shown that chronic inflammation is associated with numerous diseases, including diabetes, cancer, auto-immune diseases and cardiovascular diseases.
SUPPORTS HEART HEALTH

Vitamin B6 is involved in the breakdown of homocysteine – an amino acid which can damage artery linings when allowed to build up in circulation. Vitamin B6 helps decrease elevated homocysteine levels that lead to narrowing of arteries which are associated with heart disease risk. Epidemiologic evidence has suggested that low dietary intake or reduced blood concentrations of vitamin B6 is associated with an increased risk of cardiovascular disease. For example:

  • A study found higher dietary vitamin B6 intake levels lowered cardiovascular disease risk in men.
  • A study showed that people with low blood levels of vitamin B6 have almost double the risk of getting heart disease compared to those with higher B6 levels.
  • A randomized controlled trial involving 158 healthy adults who had siblings with heart disease found that the group that took B6 and folic acid (B9) every day for two years had lower homocysteine levels and less abnormal heart tests during exercise versus the placebo group, putting them at an overall lower risk of heart disease.
HELPS PREVENT CANCER

Some studies suggest a link between adequate dietary intake and blood levels of vitamin B6 and a decreased risk of certain types of cancer. For example:

  • A systematic review states that there is an undoubtedly strong relationship between vitamin B6 intake and the appearance of cancer, regardless of where it occurs. The strongest connection occurs in gastrointestinal cancer.
  • A review of 12 studies found that both adequate dietary intake and blood levels of B6 were associated with lower risks of colorectal cancer. Individuals with the highest blood levels of B6 had an almost 50% lower risk of developing this type of cancer.
MAINTAINS EYE HEALTH

Studies have shown that Vitamin B6 may play a role in preventing eye diseases, especially a type of vision loss that affects older adults called age-related macular degeneration (AMD). For example:

  • A study showed an association with elevated levels of homocysteine and AMD. Since vitamin B6 helps reduce elevated blood levels of homocysteine, getting enough B6 may lower the risk of AMD.
  • A controlled study involving a large cohort of women showed that daily supplementation with B6/B12/folic acid(B9) reduced the risk of AMD by 35-40%.
  • A study in over 500 people found that the lowest blood levels of B6 were significantly associated with retinal disorders.

Scroll right/left to see the benefit and links to clinical studies.

VITAMIN B5 (PANTOTHENIC ACID)

WHAT IS PANTOTHENIC ACID GOOD FOR?

Vitamin B5, also known as pantothenic acid, is one of the eight B vitamins. It contributes to:

  • normal energy-yielding metabolism
  • the reduction of tiredness and fatigue
  • normal mental performance
  • normal synthesis and metabolism of steroid hormones, vitamin D and some neurotransmitters

Good sources of pantothenic acid include chicken, beef, liver and kidneys, eggs, mushrooms and avocado.

Because pantothenic acid is a water-soluble vitamin, it cannot be stored in the body and must be obtained daily from diet or supplements.

SCIENTIFIC BENEFITS OF PANTOTHENIC ACID (B5)

Pantothenic acid has many important functions including, aiding in the adrenal glands' creation of hormones (e.g., testosterone and cortisol); converting food (carbohydrates) into fuel (glucose) which the body uses to produce energy; synthesizing cholesterol and maintaining a healthy digestive system. Furthermore, studies suggest that B5 supports skin and hair health and helps regulate stress.

Let’s delve into some of the science below:

MAINTAINS ENERGY LEVELS

As with all B vitamins, pantothenic acid helps convert food (carbohydrates) into fuel (glucose). Pantothenic acid does this by synthesizing an enzyme known as coenzyme A (CoA), which breaks down sugars in the form of glucose for energy. It’s also used to synthesize and metabolize (break down) fats and proteins so that our bodies can use them for energy and rebuilding tissues, muscles, and organs. Furthermore, studies show that Pantothenic acid (B5) contributes to the reduction of tiredness and fatigue. For example:

  • Research shows that adequate supply of each B vitamin is required for appropriate functioning of energy-production, which is important because lack of energy or a feeling of low vitality is often described as fatigue.
  • A study found that after approximately 6 weeks of induced pantothenic acid (B5) deficiency, subjects complained of headache, fatigue, insomnia, and they reported excessive fatigue after their daily walk; symptoms decreased then disappeared after 4 weeks of supplementation with 4g pantothenic acid daily.
SUPPORTS HEART HEALTH

Pantothenic acid (B5) helps to break down fats and is needed to synthesize cholesterol. A derivative of pantothenic acid is called pantethine, which has been studied for its ability to positively influence heart function, especially by maintaining normal cholesterol levels. For example:

  • A controlled study showed that pantethine, a derivative of vitamin B5 seems to help protect arteries and prevent dangerous plaque build-up that can potentially lead to heart attack or stroke.
  • A study showed that pantethine, a derivative of vitamin B5 may help reduce “bad” LDL cholesterol and triglyceride levels in the blood of people with elevated blood fats. At the same time, it helps raise “good” HDL cholesterol.
IMPROVES MENTAL PERFORMANCE

B vitamins in general, including pantothenic acid (B5), are often correlated with improving mental function. Research shows that vitamin B5 is important for neurotransmission and some studies show that cerebral deficiency in B5 may contribute to cognitive decline. For example:

  • A study found that vitamin B5 deficiency may well cause neurodegeneration and dementia in Alzheimer’s disease, which might be preventable or even reversible in its early stages, by treatment with suitable oral doses of vitamin B5.
HELPS REGULATE STRESS

Vitamin B5 is partially responsible for regulating adrenal function and supporting the balanced production of the stress hormone cortisol. It helps reduce levels of excess cortisol triggered during stress events. Evidence indicates that adrenal cortex function is compromised if we are deficient in vitamin B5 derivatives and metabolites, and consequently it can be more difficult for us recover from the effects of prolonged or chronic stress. For example:

  • Studies show that vitamin B5 may allow individuals to sustain an adaptive response and minimize some of the systemic effects of stress.
  • A study in rats, clearly demonstrated that pantothenic acid (B5) supplementation stimulates the ability of adrenal cells.
HELPS MAINTAIN HEALTHY HAIR

Vitamin B5 supplements and derivatives are used to help with a range of conditions including hair loss and dandruff. For example:

  • A study found that D-panthenol - a precursor of vitamin B5 (pantothenic acid) - stimulated hair growth.
  • A study found that D-panthenol may help slow down and hide the look of thinning hair. The study tested it with other active ingredients as a leave-in treatment.
SUPPORTS SKIN HEALTH

Some research suggests that pantothenic acid (B5) supports skin health. For example:

  • A controlled study showed that vitamin B5 helped facial acne and reduced the number of acne-related facial blemishes when taken as a dietary supplement for 12 weeks.
  • A review found that pantothenic acid supplements may speed up wound healing, especially following surgery.
FIGHTS INFECTIONS

Studies have shown that higher intake of pantothenic acid (B5) can result in a reduction in the proliferation of different harmful parasites and has been shown to inhibit the growth of dangerous bacteria. For example:

  • A study found that B5 was helpful in limiting growth of mycobacterial infection.
  • A study showed that that B5 can inhibit the growth of malaria parasites.
IMPROVES SYMPTOMS OF RHEUMATOID ARTHRITIS

Preliminary evidence suggests that pantothenic acid might improve symptoms of rheumatoid arthritis (RA). For example:

  • A study found that people with RA have lower levels of B5 in their blood, and the lowest levels were associated with the most severe symptoms.

Scroll right/left to see the benefit and links to clinical studies.

Disclaimer: HIMMENSE SHIFT is not intended to diagnose, treat, cure, or prevent any disease. Individual results will vary. Research is for information only and should not replace medical care. Consult a doctor or healthcare professional if you have any questions or are taking any other medications before you try any supplements.